Scientific Program

Day 1

KEYNOTE SPEAKERS
  • Piebaldism Associated with Neurofibromatosis Type I: A Case Report

    Dermatology Diploma (RCPSG) Glasgow, Egypt
    Egypt
    Biography

    Dr. Eslam Alshawadfy is working in Department of Dermatology research, National Research Centre, Egypt. Dr's research experience includes various programs, contributions and participation in different countries for diverse fields of study.

    Abstract

    piebaldism is a rare disorder present at birth and inherited as an autosomal dominant trait. It results from a mutation in the c-kit proto-oncogene and is associated with a defect in the migration and differentiation of melanoblasts from the neural crest. We report a 15-year-old girl with both piebaldism and neurofibromatosis type 1 (NF1). She presented with a congenital depigmented patch of the forehead, as well as acquired white forelock, depigmentation of the medial eyebrows, and depigmented patches of the legs. In addition, some café au lait macules were observed at birth on the trunk and neck. To our knowledge, the association of piebaldism and NF1 has been described previously in at least six case reports. Awareness of this rare association is relevant to ensure early diagnosis and adequate follow-up for NF1.

  • A case of infiltrative basal cell carcinoma sustaining the necessity of the thorough clinicopathological correlation

    Belarusian Medical Academy of Postgraduate Education, Belarus
    Germany
    Biography

    Svetlana Gradova was graduated from Belarusian State Medical University in 2003 (General Medicine). In 2007, she was graduated from Belarusian Medical Academy of Postgraduate Education (Dermatovenereology). She was employed with City Clinical Skin and Venereal Diseases Clinic (Minsk, Belarus) as a Dermatologist for a several years. From 2007 she has been taking a full-time course in the Clinical Residency at the Department of Dermatology, Belarusian Medical Academy of Postgraduate Education. She has published 8 papers in reputed local and European journals.

    Abstract

    Statement of the Problem: Despite, the advances in modern scientific medicine and inevitable emergence of the newest diagnostic approaches in Dermatology, many specialists continue experiencing difficulties in diagnosing T-cell skin lymphomas. There are several reasons for this uncertainty which should be thoroughly analyzed. Due to the variety of clinical forms and manifestations and frequent resemblance of cutaneous T-cell lymphomas to the different benign dermatoses, the precise diagnosis is often delayed for months and even years. Histopathological features of the discussed malignancy are also vague and subtle in many cases, especially at the early stages, which add confusion to the diagnostic process. In addition, the lack of communication between Pathologists and Dermatologists might contribute to the substantial delays in making the right diagnosis as well. The influence of such delays on patients’ outcomes cannot be overestimated, since the late diagnosing and misdiagnosing lead to the implementation of the inappropriate treatment regimens and significantly reduce their chances for the positive outcomes. The purpose of my speech is to share my own clinical experience and challenges encountered on the way to the diagnosis of cutaneous T-cell lymphoma, as well as to analyze the possible barriers to the timely diagnosis and the ways for their potential resolution.

  • Avoiding psychological pitfalls in aesthetic medical procedures

    Meijia Plastic Surgery Hospital, China
    China
    Biography

    Qiuyu Wang has engaged in the Professional Cosmetic Dermatology and Plastic Surgery for more than 15 years in a variety of hospital and community settings in China. In 2008, she has a Visiting Scholar, visited Korea Dermatology Group Institution. She has considerable experience in providing a variety of clinical treatment and educational activities related to dermatology and non-invasive or minimally invasive aesthetic treatment, especially in the field of photoelectric treatment, non-invasive treatment and fat transplantation. She has participated in National High Technology Research and Development Program (863 Program), National Natural Science Fund Project and published many articles in recent years. Her innovation is also reflected in her patents (5 items) and a co-author of book Threads and Consultation was published in 2017, and is the first of its kind to combine threads lifting skills and counseling skills to provide a practical resource for managing patients with improvement of aesthetic patient satisfaction.

    Abstract

    Statement of the Problem: According to the research of Cash and Henry, about half of American females have a negative evaluation of their own appearance. In German population-based surveys, approximately 40% of female participants reported that they had a preoccupation with one part of their body appearance. This is arguably the main reason for people undergoing aesthetic procedures. Culturally, Chinese people would like to have a body image because this may have positive effects in many ways (i.e. producing more job opportunities, finding a partner more easily and enhancing self-confidence). Hence, more Chinese are undergoing body image change using aesthetic procedures. Nevertheless, not these people have the correct perspective on their physical appearance, such as patients with body dysmorphic disorder. Objective: To assess the prevalence of Body Dysmorphic Disorder (BDD) in an aesthetic surgery setting in the region of Southwest China, and to ascertain the differences in terms of body images between patients in the aesthetic setting and general Chinese population. This study tracked patients’ satisfaction with their body image changes while undergoing aesthetic medical procedures to identify whether the condition of patients who were presenting with BDD symptoms or their psychological symptoms could be improved by enhancing their appearance. Additionally, this study explored whether there was improvement in Quality of Life (QoL) and self-esteem after aesthetic medical procedures. Methods: 106 female patients, who were undergoing aesthetic medical procedures for the first time, were classified as having body dysmorphic disorder symptoms or not having body dysmorphic disorder symptoms, based on the Body Dysmorphic Disorder Examination (BDDE), which was administered preoperatively. These patients were followed-up for one month after the aesthetic procedures. Multidimensional Body Self-Relations Questionnaire-Appearance Scales (MBSRQ-AS) and Rosenberg Self-esteem Scale (RSE-S) were used to assess patients’ preoccupation with appearance and self-esteem pre-procedure and one-month post-procedure. Additionally, 100 female healthy control participants were recruited as a comparative group into this study and they were also assessed using BDDE, MBSRQ-AS and RSE-S. Results: A total of 14.2% of 106 aesthetic patients and 1% of 100 healthy controls were diagnosed with BDD to varying extents. BDDE scores were 72.83 (SD+30.7) and 68.18 (SD+31.82) respectively in pre-procedure and post-procedure for the aesthetic patient group and 43.44 (SD+15.65) for the healthy control group (F=34.28; p<0.001). There was a significant difference between the groups in subscales of MBSRQ-AS between groups. The study also showed there were no significant differences in the scores of BDDE, MBSRQ-AS and RSE-S of those fifteen aesthetic patients diagnosed with BDD after aesthetic procedures lasting one month. Conclusion: There was a high prevalence rate (14.2%) of body dysmorphic disorder in aesthetic seekers and it seemed that these patients suffering from BDD were more likely to be dissatisfied with the results of the aesthetic medical procedures. However, general aesthetic patients showed improvement in most assessments which indicated aesthetic medical procedures could not only enhance patients’ appearance, but also the patients’ low self-esteem and QoL. Self-satisfaction would also be promoted. A suitable screening procedure for BDD and valuable screening questionnaires might be considered for routine use in aesthetic clinical settings to minimize dissatisfaction and complaints.

  • Attentiveness of dermatologists in the middle east for the practice psychodermatololgy

    United Arab Emirates University, UAE
    USA
    Biography

    Ossama Tawakol Osman is certified in Psychiatry by the American Board of Psychiatry and Neurology and has been elected a fellow of the American Psychiatric Association. He completed residency training at SIU-in Illinois, USA and a research fellowship in clinical psychopharmacology at the National Institute of Mental health (NIMH) in Bethesda, Maryland. His academic career is focused on bridging clinical research and practice through community clinical, research, and educational program development and had an extensive and diverse international experience. At USF in Tampa, Florida he developed the psychiatric research program at the Bay Pines VAMC. At SIU he helped to develop the academic research program in developmental disabilities in Illinois. At Mercer University in Georgia, he developed the mental health community-wide programs in substance abuse, mental health and developmental disabilities. In Saudi Arabia, he helped develop the substance abuse and addiction services for the western region of the kingdom through his capacity as the Medical Director of Al-Amal Hospital-Jeddah 1999-2004. In the UAE research activities emphasized epidemiologic community studies in the primary care and interdisciplinary clinical outcomes research. Organizational involvement is a past president of American-Arab Psychiatric Association, Member of scientific/executive councils for the Arab Board of Psychiatry and Chairperson for its Committee on Curriculum/Accreditation/Credentialing.

    Abstract

    Background: Many dermatologic patients suffer from coupled psychiatric symptoms. Proper treatment of these patients requires parallel psychiatric care. The main objective of this study was to assess awareness of Middle East dermatologists to psychocutaneous medicine. Methods: This study utilized a survey that was originally developed for dermatologists in the Upsychodermatology’ describes the psychiatric aspects of skin diseases as well as the dermatologic manifestations of psychiatric problems. Results: 57 dermatologists from United Arab Emirates, Saudi Arabia, Egypt, Kuwait, Iraq, Jordan and Lebanon completed the survey. 49 (86%) reported clear understanding of the term psychodermatololgy, nine (16%) were very comfortable in diagnosing and treating these disorders, and 52 (91%) were unaware of patient/family resources on psychodermatology (e.g., association for psychoneurocutaneous Medicine of North America, European Society for dermatology and psychiatry, psychodermatology UK, and Japanese Society of Psychosomatic Dermatology). Acne, alopecia, vitiligo, atopic dermatitis, and psoriasis were common skin diagnoses coupled with psychiatric manifestations. 13 (23%) dermatologists expressed interest in attending educational activities on managing psychodermatologic diseases. Conclusion: Patients who had psycho cutaneous disorders might not receive necessary care because of insufficient experience in managing their problems. This survey supports the need for incorporating formal training on psychodermatololgy in postgraduate dermatology programs. There is also a need for establishing dermatology–psychiatry limited states to assess regional experience with psychodermatololgy disorders. The reasons especially acquainted with managing the patients.

Clinical Dermatology | Diagnostic Techniques in Dermatology | Dermatological Oncology | Dermatology: Therapies & Advances
Chair
Speaker
  • New possibilities for prolonging remission with vitiligo
    Time: 12:30-13:00
    Speaker
    Dr. Kassymkhanova Aliya,
    Regional Dermatovenerology Center of South Kazakhstan, Kazakhstan
    Algeria
    Biography

    Kassymkhanova heads the Physiotherapy Department of the Regional Dermatovenereology Center of South Kazakhstan. She has been actively involved in vitiligo research since 2004. Dr. Kassymkhanova published over 20 papers and received two patents for vitiligo treatments. A tireless patient advocate, Aliya chairs the Vitiligo School - a local patient education and support group she founded in 2005.

    Abstract

    Abstract: The article discusses the necessity of prophylactic measures after successful completion of vitiligo treatment aiming to prevent the recurrence of the disease. Based on the available scientific data, the complex of measures for prophylactics is suggested. Observations of 298 vitiligo patients after treatment are presented, which confirm efficiency of the proposed measures which allowed for reaching remissions of more than 4 years in 42% of patients, with the maximal remission length being 9.5 years. NB-UVB phototherapy has been complexed with balneotherapy and pharmaceuticals for 298 vitiligo patients with depigmentation of more than 15% of body surface area. Clinical success (repigmentation 95%-100%) was observed in 19 (6%) of the patients, significant improvement (repigmentation from 50% to 95%) was seen in 178 patients (60%). Improvement (repigmenttaion ranging from 15 to 50%) was observed in 96 patients (32%), and lack of clinical effect (repigmentation less than 15%) was noted in 5 patients . The average number of phototherapy sessions was 97±9, cumulative NB-UVB dosage was 82.37±4.46 J/cm2. The duration of phototherapy course was on average 15 months. 22 surgical transplants were performed: transplantation of a suspension of uncultivated epidermal cells - keratinocytes and melanocytes and transplantation of a suspension of uncultivated cells of the outer root vagina of hair follicles. Results: repigmentation of 95% -100% was observed in 7 (32%), repigmentation of 50% -95% was in 10 (45%), repigmentation of 15% -50% in 3 (14%) and repigmentation to 15% - was in 2 (9%). Currently, the main goal of this treatment is to stop the disease from progressing and to make it stable while regressing clinical signs of vitiligo (depigmentation). Besides that, lengthy treatment, significant spending and anxiety of a patient to return back to the past condition require to search for novel prophylactics measures. which, in turn, can lead to vitiligo recurrence. This further points to the necessity of continuing treatment. The view of photo-immunology has changed over the past several years (Ullrich and Byrne, 2012). The mechanisms involved are much more complex than initially thought. Low/physiologic doses of UVR inhibit the adaptive immune system but induce parts of the innate immune system. This is in line with the fact that ambient solar exposure is crucial and physiologic. Thus, it is fair to speculate that a certain level of constant immunosuppression by daily solar exposure may prevent the induction of such adverse immune responses, but this must be confirmed by future studies (Schwarz T, Beissert S, 2013).

  • Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: A concurrent split-face study
    Time: 14:00-14:30
    Speaker
    Dr. Mohd Asif
    Naushad Medical Centre, India
    India
    Biography

    Mohd Asif a senior resident, Department of Dermatology, Muzaffarnagar Medical College, U.P, India. 2016, Consultant dermatologist in Kaya Skin clinic, Delhi, India. 2017. Evaluated role of platelet rich plasma in acne scars-“Combined autologous platelet rich plasma with microneedling verses Microneedling with distilled water in the treatment of atrophic Acne scars: A concurrent split face study” Published in “Journal of Cosmetic Dermatology” 8th Jan 2016. Member of Indian medical association (IMA), Member of Indian association of dermatology, Venereology, and leprosy (IADVL), Member ofAssociation of cutaneous surgeons of India.

    Abstract

    BACKGROUND: -. Acne scars are the squeal of acne; which causes cosmetic discomfort, depression, low self-esteem & reduce quality of life. Microneedling is an established and cost effective treatment for scars, although the efficacy of platelet-rich plasma (PRP) has not been explored much. OBJECTIVE: - The objective of this study was to evaluate the efficacy and safety of platelet-rich plasma (PRP) combined with microneedling for the treatment of atrophic acne scars. METHODS: - Sixty two patients of 17–34 years of age with atrophic acne scars were enrolled. Microneedling was performed on both halves of the face. Intradermal injections as well as topical application of PRP (pre activated with calcium chloride) was given on right half of the face, while the left half of the face was treated with intradermal administration of distilled water. Three treatment sessions were given at an interval of 1 month consecutively. Goodman's Quantitative scale and Quantitative scale were used for the final evaluation of results. All the adverse effects were duly noted and treated. RESULTS: -. Right and left halves showed 62.37% and 46.62% improvement, respectively, on Goodman's Quantitative scale. Goodman's Qualitative scale showed excellent response in 25 (40.32%) patients and good response in 37 (59.68%) patients over right half of the face, while the left half of the face showed excellent response in 8 (12.90%) patients, good response in 49 (79.03%) patients and poor response in 5 (8.06%) patients. CONCLUSION: - We conclude that PRP is safe and efficacious in the management of atrophic acne scars when combined with microneedling. It can be also be combined and researched with other existing modalities of treatment.

  • Significant lightening effect of a whitening formula (AE brightening complex-01) compared to 4% hydroxyquinone
    Time: 14:30-15:00
    Speaker
    Dr. Saadiah S
    Annur Skin Specialist Clinic, Malaysia
    Malaysia
    Biography

    Saadiah S has completed her graduation from Royal College of Surgeons, Ireland in 1987, currently a Consultant Dermatologist (as per Malaysia National Specialist Register) serving Damansara Specialist Hospital, Seremban Specialist Hospital and Annur Specialist Hospital in Malaysia. She was a Consultant Dermatologist in Hospital University Kebangsaan, Malaysia, Committee Member of the Advance Masters Dermatology Program, which she has set up in year 2000 in University Kebangsaan Malaysia (UKM), where she has served from year 1992 to 2003 and attained her Postgraduate degree, Masters in Internal Medicine and further trained by the world renowned Dermatologist, Professor Malcolm Greaves. Since then, she has supervised and trained many young dermatologists. Being actively involved in research, apart from many journal publications and conference presentations, she heads the dermatology clinical laboratory research and has successfully established two MS ISO 17025 accredited laboratory, Makmal Bioserasi for research and development and testing of healthcare products in Malaysia.

    Abstract

    Introduction: Fair skin complexion is much preferred by the Asian population. Four percent hydroquinone has been known to be effective as a whitening agent albeit unwanted effects such as worsening pigmentation, onchronosis and irritation have been well documented. This study aims to compare the lightening effects and the safety profile of a novel topical formulation derived from Vitamin C in combination with plant’s extract, known as AE Brightening Complex- 01 with a standard formulation containing four percent Hydroquinone. A case control study was conducted to evaluate the efficacy of AE Brightening Complex-01 versus 4% Hydroquinone cream in lightening normal skin colour. Materials & Methods: AE Brightening Complex-01 contains refined stabilized vitamin C complex and plant’s extract as active ingredient. All 20 subjects were applied with AE Brightening Complex-01 on their right arm, 4% hydroquinone on their left arm twice a day for 28 days. Their left forearm was left untreated. Visual and colorimeter assessment of the right arm, left arm and left forearm were done on day 0, Day7, Day 14, Day 21 and Day 28. Results: Skin areas treated with AE Brightening Complex-01 showed significant degree of lightening effect (+1.69) after 21 days of treatment compared to areas treated with 4% hydroquinone (+0.47) and untreated area (+0.13). This was tested using Skin Colorimeter Konica Minolta CR 10. There was further improvement at day 28 of the treated area with AE Brightening Complex-01 (+1.96), 4% hydroquinone (+0.66) and untreated area (-0.09). The AE Brightening Complex-01 formulation showed significant skin lightening effect compared to standard 4 % Hydroxyquinone with p<0.05. Conclusion: The AE Brightening Complex-01 formulation is significantly effective to lighten normal skin colour compared to 4% Hydroquinone.

Day 2

KEYNOTE SPEAKERS
  • Significant lightening effect of a whitening formula (AE brightening complex-01) compared to 4% hydroxyquinone

    Annur Skin Specialist Clinic, Malaysia
    Malaysia
    Biography

    Agnieszka Owczarczyk-Saczonek is Assistant Professor of the Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology at The University of Warmia and Mazury in Olsztyn. She was appointed as the Consultant in dermatology and veneorogy of Warmian-Masurian Voivodeship in 2013. Moreover she is a Member of the Polish Society of Dermatology, a Member of the Association of Aesthetic Dermatology, and a Member of the European Academy of Dermatology and Venereology.

    Abstract

    Introduction: Psoriatic patients, especially with psoriatic arthritis (PsA), are more prone to metabolic disorders and involving the eyes. Aim: The aim of this study was presentation adalimumab efficacy of several aspects of psoriasis and its comorbidities. Material & Methods: We present a 48-year-old male patient with severe plaque psoriasis and PsA who developed uveitis with cystoid macular oedema in the right eye. The patient was obese although bariatric surgery eight years earlier produced some weight loss with remission of diabetes and hypertension. Results & Discussion: The patient had been previously treated with systemic treatment with no improvement in PsA symptoms and skin lesions but rapidly responded to adalimumab. At week 8, the patient achieved the PASI 75, with no joint pain and normal macular architecture. At week 16, there was an incident of atrial fibrillation followed by a transient ischaemic attack (TIA). The TIA subsided after intravenous fluids and antithrombotic treatment although acute urticaria developed after the first dose of acetylsalicylic acid. Adalimumab treatment was not stopped and the patient’s condition continued to improve. Conclusions: After careful consideration of the patient’s underlying and comorbid conditions and previous treatment failures, adalimumab was instituted and continued since its efficacy in psoriasis and PsA is well-documented; obesity is not thought to affect its effectiveness; inuveitis adalimumab acts quickly and induces long-term remission and a significant improvement of hemostasis and fibrynolytic balance has been observed in patients on TNF-? inhibitors and adalimumab could be continued after the TIA.

  • Mite fauna investigation followed by scientific mite elimination is essential in treating severe and intractable atopic dermatitis

    Meguro Chen Dermatology Clinic, China
    China
    Biography

    Hideo Nakayama was the Chief Dermatologist in Tokyo Saiseikai Central Hospital from 1970 to 1995. He was the Visiting Lecturer of Keio University, School of Medicine, from 1973 to 1995, Chief Dermatologist and Allergologist at Nakayama Dermatology Clinic from 1995 to 2015. He has graduated from Keio University, School of Medicine in 1961. Currently, he is the Advisor Doctor in Meguro Chen Dermatology Clinic (Tokyo). He has discovered new allergens, such as palladium, benzyl salicylate, R-219 (D&C R-31), ylang-ylang oil, ?-acaridial, etc., and developed new treatment systems by allergen control with pigmented cosmetic dermatitis, textile dermatitis, dental metal allergy and atopic dermatitis.

    Abstract

    To stop the relapse of severe eczema of long lasting atopic dermatitis (AD), the investigation of mite fauna in the patients’ homes is essential. When the mite number of more than 10 places in the homes, it is reduced to less than 50/m2/20 seconds aspiration by 320W vacuum cleaner, actual mite number 10 cm*10 cm area becomes less than 1 mite, and this is the threshold lower than provoking and maintaining eczema. This theory was based on the fact that crashed three live mites were necessary to produce clear positive reactions by patch testing, and only one mite was not enough to provoke eczema. Double blind clinical test proved this fact, using methylene blue agar (MBA) method to count the mite numbers of macroscopically invisible mites in the houses. The introduction of mite-free-mattress, heater-flooring, removal of carpets etc. has been effective to decrease the mite number to less than 50/m2. Photographs and statistics of the remarkable effects of mite elimination on severe AD cases are demonstrated.

Dermatological Diseases | Cosmetic Dermatology | Allergy | Cosmetic Surgeries | Aging Dermatology
Chair
Speaker
  • Associations between air pollution, climate factors and outpatient visits for eczema in West China Hospital, Chengdu, Southwestern China: A time series analysis
    Time: 11:20-11:50
    Speaker
    Dr. Anqi Li
    West China School of Medicine, China
    China
    Biography

    Anqi Li, a student in West China School of Medicine, Sichuan University, who is studying for the master degree under Professor LI Li. My study research is about the air pollution and skin diseases especially skin allergy. During my study in university I am a top student and have been awarded The First-class Scholarship, Excellent Student Leader Scholarship for my high grades, excellent performance in examinations and devotion to the services to the Student Association. I worked for 2 years in outpatient department of dermatology and 6 months in hospitalized wards of dermatology in West China Hospital, Sichuan University. The major work was involved in diagnosis and treatment of daily general skin problems. Also I actively participated in overseas student teaching program in the ward of dermatology.

    Abstract

    Environmental irritants are important risk factors for skin diseases, but little is known about the influence of environmental factors on eczema incidence. In this timeseries study, our objective was to examine the associations of environmental factors with outpatient visits for eczema. Daily outpatient visits between 2007 and 2011 (1826 days) were collected from Huashan Hospital in Shanghai, China. We used an over dispersed generalized additive model to investigate the short-term association between environmental factors and outpatient visits for eczema. Daily outpatient visits for eczema were significantly associated with air pollution and meteorological factors. For example, a 10 ?g/m3 increase of 7-day (lag 06) average concentrations of PM10 (particulate matter no greater than 10 microns), was associated with 0.81% (95% confidence intervals (CI) 0.39%, 1.22%), 2.22% (95% CI: 1.27%, 3.16%) and 2.31% (95% CI: 1.17%, 3.45%) increase in outpatient visits for eczema, respectively. A 10 °C elevation of temperature on lag 0 day were associated with 8.44% (95% CI: 4.66%, 12.22%) increase in eczema visits, whereas 10 unit decrease of 7-day average relative humidity were associated with 10.86% (95% CI: 8.83%, 12.89%) increase in eczema visits. This study provided clear evidence of ambient air pollution, high temperature and low relative humidity on increasing the incidence of eczema in Shanghai, China.

  • Non-Invasive Characterization of Allograft Dermis, Skin and Scar Using Vibrational OCT
    Time: 11:50-12:20
    Speaker
    Dr. Frederick H Silver
    Rutgers University in Piscataway, USA
    USA
    Biography

    Frederick H. Silver is a Professor of Laboratory Medicine and Pathology at Robert Wood Johnson Medical School, Rutgers University in Piscataway, NJ. He did his Ph.D. in Polymer Science and Engineering at M.I.T. with Dr. Ioannis Yannas, followed by a postdoctoral fellowship in Developmental Medicine at Mass General Hospital with Dr. Robert L. Trelstad. Over the last 40 years, he has taught biomedical engineers and physicians at Mass General Hospital, Boston University, Rutgers University and University of Minnesota. His research interests include connective tissue disorders, collagen self-assembly, tissue mechanical properties, pathobiology of implants, mechanobiology and non-invasive assessment of disease processes. He has published over 170 research papers and book chapters and is co-inventor on over 20 patents.

    Abstract

    Physicians have been palpating dermal lesions for over 100 years to assist in the diagnosis of disease. Recently, several papers report that cancerous lesions are stiffer (harder) than normal tissues. These events have led to over 40 years of research attempting to develop mechanical tests that can non-invasively and non-destructively evaluate the mechanical properties of skin in health and disease. My lab has measured the mechanical properties of a number of extracellular matrices including skin, decellularized dermis and chemically modified dermis for over 30 years. The mechanical behavior of skin is complicated by several factors including: (1) time dependence of the behavior (viscoelasticity); non-linearity of the stress-strain behavior; (3) ability to test tissue fragments without mechanical slippage during testing; (4) directional dependence of the properties along and perpendicular to Langer’s Lines; (5) assumption that Poisson’s ratio is independent of strain; and (6) age dependence of the stiffness of skin. All these variables make measurement and interpretation of the stiffness (modulus) and its dependence on deformation (strain) of skin very complex. Recently, we reported the use of optical cohesion tomography (OCT) in combination with vibrational analysis to measure the stiffness of normal skin and scar tissue as well as that of decellularized and chemically modified dermis (Shah et al., 2016, 2016a, 2017). In this technique skin is vibrated using a speaker that employs a low intensity sound wave generated by a cell phone app to find the resonant frequency of skin. This is done by measuring the frequency by OCT at which maximum deformation of the sample occurs. The frequency at which maximum deformation occurs is related the stiffness of a material and tissue properties such as the density. The purpose of this talk is to summarize the results of calibration measurements made on skin and processed dermis in vitro, as well as to show how this technique has been applied to measuring the modulus and imaging skin and scar tissue in vivo. Although Poisson’s ratio increases with strain and skin is compressible, measurements made along and perpendicular to Langer’s Lines show not only the characteristic stiffness of elastic fibers in the low strain region (0.060-0.75 MPa), but a transition to the stiffness of collagen fibers with a modulus of about 2 to 5 MPa at higher strains. It is concluded the strain in normal skin from the hand in vivo is approximately 2% under unloaded conditions along Langer’s Lines and that using Vibrational OCT provides a method to do “mechanical spectroscopy” on the macromolecular components of skin. These results suggest that Vibrational OCT may be useful in the imaging and diagnosis of skin pathologies as well as in evaluating the effects of treatments that are aimed at improving wound healing and softening aged skin.

  • Tattoo and warts: Efficacy of topical immunotherapy
    Time: 12:20-12:50
    Speaker
    Dr .Luca Fania
    Dermopathic Institute of the Immaculate Conception, Rome
    Italy
    Biography

    Luca Fania is Chief Medical Officer of Bone Dermatologist at IRCCS Dermopathic Institute of Immigration (IDI) in Rome and Dermatologist Consultant at the private Villa Stuart, Rome. He was the winner of the PhD in Oncology Sciences at the A GemelliHospital in Rome and therefore deals with Dermatological Surgery of organ transplant patients and carries out a research project in the skin cancer of transplanted patient’s organ. He specializes in lode in dermatology and venereology at the Catholic University of the sacred heart of Rome and has held the internship as Attendant Physician at the Institute of Clinical Dermatophilopathy of the University Hospital A Gemelli of Rome.

    Abstract

    In recent decades, the practice of tattooing has greatly diffused and is performed worldwide. During this practice, many infections can transmit as Human papillomavirus that can present after weeks of months with viral warts. The inoculation of the dye can promote an altered local immune response area, named immunocompromised district that can lead, after long latency period from the practice of the tattoo, to cutaneous disorders. We present two cases of multiple viral verruca localized on polychrome tattoo that were performed many years before. This skin infection has been successfully treated with contact immunotherapy that is squaric acid dibutylester (SADBE), without alterations of the tattoos

  • Treatment of vitiligo at home with portable devices using the narrow-band phototherapy method in the rays of 311 nm
    Time: 14:30-15:00
    Speaker
    Dr. Smirnova Olga Mikhailovna
    Akmola Medical Academy, Kazakhstan
    Algeria
    Biography

    Smirnova Olga Mikhailovna is a Dermatologist. She works in a private clinic, where she is the Director and she practices Medicine. She is treating vitiligo with the method of narrow-band phototherapy. Currently, she has about 100 people treated with vitiligo,they receive the device three times a week, to the scheme. About 200 people in Kazakhstan are under her supervision and on treatment at home with local apparatus. At the dispensary registration, there are 800 people.

    Abstract

    Background & Purpose: Narrow-band phototherapy is the main method of vitiligo treatments. The purpose of this study is to illuminate the phototherapy treatment regimens at home, to show skin care with long-term treatment and vitiligo narrow-band treatment. This shows that this method of treatment is very effective and available to every patient. Material & Methods: The author represents patients, children, and aged 5 to 10 years their result of treatment before and after treatment. Results & Discussion: The patient, 5 years old, turned to the Dermatologist with the spread form of vitiligo for help. The portable device of firm Kernel, which I registered on territory of Kazakhstan was offered. Through 100 procedures of phototherapy, 90% of white spots were depigmented. Six more cases of depigmentation of the skin in the home will be described. Given the basic rules of phototherapy in the home. Given a table on which patients can themselves, at home to be treated. Presentations will highlight the benefits of vitiligo treatment at home. Conclusions: The method of treating vitiligo at home with portable devices using the narrow-band phototherapy method is very accessible, effective, beneficial and simple.

  • Prevalence and determinants of eczema among females aged 21 to 32 years in Jeddah city, Saudi Arabia
    Time: 15:00-15:30
    Speaker
    Dr. Sultana Alnahdi
    Ibn Sina National College, Saudi Arabia
    Saudi Arabia
    Biography

    Sultana Alnahdi is a Medical student and recently a Medical Intern in Security Force Hospital in Jeddah, kingdom of Saudi Arabia. She has been studying in Ibn Sina Medical College in Jeddah, and graduated in 2017. She has been engaged in various Dermatology Clinics during her Medical studying years, particularly, immuno-dermatology and cosmetics. She has an eczema research which has been published. She is working towards to become an Immuno-Dermatologist, which will be done from her internship in July of 2018.

    Abstract

    Introduction: Atopic dermatitis (AD) is a common, chronic an inflammatory skin disease with early onset and with a lifetime prevalence of approximately 20%. Although, the pathogenesis of the disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental, and infectious agents and immune abnormalities. Aim: The aim of this study is to investigate the prevalence and determinants of Eczema among Saudi female aged 21 to 32 years old in Jeddah city. Methods: A cross-sectional study involved 190 female students from Ibn Sina National College for Allied Health Sciences in Jeddah city were chosen by convenient sampling. Data were collected by interview questionnaire (ISAAC: core questionnaire for asthma, rhinitis and eczema) after getting their consent. SPSS used for data entry and analysis. Results: Prevalence of eczema among medical college females was 16.6%, eczema was similar in Saudi and non-Saudi females (13.97% and 12.66% respectively, P=0.545). Eczema was associated with eye allergy (34.2%) with statistical significance P=0.003. Eczema was associated family members history with statistical significance P=0.012. There was not statistical significant relationship between eczema and education level, parental jobs, drugs chest and nose allergy. Conclusion: Prevalence of eczema among female medical students was 16.6%. Eczema was significantly associated with eye allergy

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